In a medium mixing bowl, whisk together the buttermilk and hot sauce, if using. Add the chicken tenders, ensuring they are submerged. Cover and refrigerate for at least 1 hour, or overnight for more flavor.
In a separate bowl, combine the flour, paprika, garlic powder, onion powder, salt, black pepper, and cayenne pepper. Whisk until evenly mixed.
In a deep skillet or frying pan, pour in about an inch of oil and heat over medium-high. The oil is ready when a drop of batter sizzles.
Remove the chicken from the buttermilk, letting excess drip off. Dredge each tender in the seasoned flour mixture, coating thoroughly.
Carefully add the coated chicken tenders to the hot oil, frying in small batches. Cook for 5-7 minutes on each side until golden brown and cooked through, with an internal temperature of 165°F (75°C).
Transfer the cooked chicken fingers to a wire rack or paper towels to drain excess oil.
Notes
For a delightful presentation, serve with crinkle-cut fries and a tangy dipping sauce.